29/07/20 Marks Hall Arboretum & 9th line

Woke up yesterday to a bright sunny morning, confirming our plan to go to Marks Hall Arboretum https://www.markshall.org.uk/ and photos but by the time we were ready to go it had turned cloudy and grey with a sharp wind. But we went anyway and had a good long walk/roll including the walled garden and both lakes. The car park was fuller than I've ever seen it before but there's plenty of room for everyone there and it was easy to keep a safe distance. Best walk I've had for a while, and it was something I needed. Most of the slightly negative thoughts that have been creeping in over the last few days didn't put in an appearance.

A message on the Facebook group from someone who says "Well today I started my 9th line of treatment 😉 Selinexor, Velcade and of course the lovely Dexamethasone."

9th line?? Several people have queried that. I don't think I've heard of anyone getting further than fifth line before. I had to look up Selinexor - it's new and interferes with communication across the nuclear membrane, meaning that cancer cells can't make the things they need to reproduce and mark themselves for destruction. That would be great if there weren't complications, but there are (mainly it increases susceptibility to infections, including fatal ones). Wikipedia says (confirmed by more reliable sources!):

Selinexor is approved for use in combination with the steroid dexamethasone in people with relapsed or refractory multiple myeloma who have received at least four prior therapies and whose disease is refractory to at least two proteosome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody (so-called "quad-refractory" or "penta-refractory" myeloma),^[9] for whom no other treatment options are available.^[3][6] It is the first drug to be approved for this indication.^[10]

So I won't be getting that one for a while!